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. 1985 Sep;4(9):2245-8.
doi: 10.1002/j.1460-2075.1985.tb03921.x.

Human proto-oncogene c-mos maps to 8q11

J F Caubet, D Mathieu-Mahul, A Bernheim, C J Larsen, R Berger

Human proto-oncogene c-mos maps to 8q11

J F Caubet et al. EMBO J. 1985 Sep.

Abstract

The c-mos proto-oncogene is the cellular counterpart of the viral oncogene v-mos isolated from Moloney murine sarcoma virus. The c-mos gene locus has previously been assigned to human chromosome 8. By both in situ hybridization and molecular hydridization to sorted chromosome DNA (using a c-mos probe) we have localized the c-mos gene to band 8q11. This regional localization is at variance with the one previously reported at 8q22 and may explain why no rearrangement of c-mos has been found in acute leukaemia with the chromosomal translocation t(8;21)(q22;q22).

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