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. 1985 Oct 22;116(3):323-6.
doi: 10.1016/0014-2999(85)90170-0.

Functional evidence for the existence of adenosine receptors in the human heart

M Böhm, W Meyer, A Mügge, W Schmitz, H Scholz

Functional evidence for the existence of adenosine receptors in the human heart

M Böhm et al. Eur J Pharmacol. .

Abstract

Adenosine added to isolated electrically driven preparations of human ventricular heart muscle antagonized the positive inotropic effect of isoprenaline (mean EC50 19 mumol 1(-1), n = 9). Similar effects were observed with the adenosine receptor agonist (-)-N6-phenylisopropyladenosine (mean EC50 0.5 mumol 1(-1), n = 7). These data provide functional evidence for the existence of adenosine receptors in the human myocardium which may modulate the force of contraction during beta-adrenergic stimulation and thus could be involved in the autoregulation of myocardial contractility.

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