Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug;16(2):1579-1583.
doi: 10.3892/ol.2018.8772. Epub 2018 May 22.

Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway

Hui Dai  1 , Hou-Bo Deng  2 , Ya-Hong Wang  2 , Jia-Juan Guo  3
Affiliations

Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway

Hui Dai et al. Oncol Lett. 2018 Aug.

Abstract

The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed that resveratrol significantly inhibited the proliferation of MGC-803 cells in a dose-dependent manner. Resveratrol induced apoptotic morphological changes in MGC-803 cells. Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, β-catenin, c-myc, and cyclin D1, at the mRNA and protein levels. Overall, resveratrol inhibits the growth of MGC-803 cells by inhibiting the Wnt signaling pathway. This study provides a new idea and direction for the antitumor mechanism of resveratrol.

Keywords: Wnt/β-catenin signaling pathway; gastric cancer cells; resveratrol.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
In the 48 h treatment with different concentrations of resveratrol, the effect on the MGC-803 cell morphology was observed under an inverted microscope.
Figure 2.
Figure 2.
Resveratrol inhibits the expression of β-catenin, c-myc, and cyclin D1 mRNA in MGC-803 cells. Compared with the control group, the expression levels of β-catenin, c-myc and cyclin D1 in each group with different levels of resveratrol were significantly inhibited, **P<0.01.
Figure 3.
Figure 3.
Resveratrol inhibits the expression level of β-catenin, c-myc, and cyclin D1 proteins in MGC-803 cells by western blot analysis. (A) β-catenin, c-myc, and cyclin D1 proteins. (B) Gray scale analysis of β-catenin, c-myc, and cyclin D1 proteins, **P<0.01.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lv Y, Song L, Chang L, Liu Y, Zhang X, Wang Y, Wang L, Liu W. Bevacizumab followed by chemotherapy is potential therapy for gastric cancer. J BUON. 2016;21:1466–1470. - PubMed
    1. Shu B, Lei S, Li F, Hua S, Chen Y, Huo Z. Laparoscopic total gastrectomy compared with open resection for gastric carcinoma: A case-matched study with long-term follow-up. J BUON. 2016;21:101–107. - PubMed
    1. Shen YH, Xie ZB, Yue AM, Wei QD, Zhao HF, Yin HD, Mai W, Zhong XG, Huang SR. Expression level of microRNA-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological staging of the cancer. Eur Rev Med Pharmacol Sci. 2016;20:1283–1287. - PubMed
    1. Zhou SF, Yin JB, Yang H, Zhong J, An P. Application value of stomach filling ultrasonography and intravenous contrast agents in diagnosis of advanced gastric cancer. Eur Rev Med Pharmacol Sci. 2016;20:3206–3210. - PubMed
    1. Zhang N, Wang AY, Wang XK, Sun XM, Xue HZ. GAS5 is downregulated in gastric cancer cells by promoter hypermethylation and regulates adriamycin sensitivity. Eur Rev Med Pharmacol Sci. 2016;20:3199–3205. - PubMed