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. 2018 Aug;16(2):1579-1583.
doi: 10.3892/ol.2018.8772. Epub 2018 May 22.

Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway

Hui Dai  1 , Hou-Bo Deng  2 , Ya-Hong Wang  2 , Jia-Juan Guo  3
Affiliations

Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway

Hui Dai et al. Oncol Lett. 2018 Aug.

Abstract

The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed that resveratrol significantly inhibited the proliferation of MGC-803 cells in a dose-dependent manner. Resveratrol induced apoptotic morphological changes in MGC-803 cells. Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, β-catenin, c-myc, and cyclin D1, at the mRNA and protein levels. Overall, resveratrol inhibits the growth of MGC-803 cells by inhibiting the Wnt signaling pathway. This study provides a new idea and direction for the antitumor mechanism of resveratrol.

Keywords: Wnt/β-catenin signaling pathway; gastric cancer cells; resveratrol.

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Figures

Figure 1.
Figure 1.
In the 48 h treatment with different concentrations of resveratrol, the effect on the MGC-803 cell morphology was observed under an inverted microscope.
Figure 2.
Figure 2.
Resveratrol inhibits the expression of β-catenin, c-myc, and cyclin D1 mRNA in MGC-803 cells. Compared with the control group, the expression levels of β-catenin, c-myc and cyclin D1 in each group with different levels of resveratrol were significantly inhibited, **P<0.01.
Figure 3.
Figure 3.
Resveratrol inhibits the expression level of β-catenin, c-myc, and cyclin D1 proteins in MGC-803 cells by western blot analysis. (A) β-catenin, c-myc, and cyclin D1 proteins. (B) Gray scale analysis of β-catenin, c-myc, and cyclin D1 proteins, **P<0.01.
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