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Comparative Study
. 1985;36(3):357-62.
doi: 10.1016/0378-1119(85)90191-x.

Sequence comparison of human and murine erythrocyte alpha-spectrin cDNA

P J Curtis, A Palumbo, J Ming, P Fraser, L Cioe, P Meo, S Shane, G Rovera
Comparative Study

Sequence comparison of human and murine erythrocyte alpha-spectrin cDNA

P J Curtis et al. Gene. 1985.

Abstract

The results of hybridization analyses using cDNA probes for mouse and human alpha-spectrin mRNA indicate that a single gene encodes the alpha-subunit of erythrocyte spectrin. Sequencing of the cDNA clones showed that they code for 370 amino acids (aa) covering three repeat domains close to the C terminus of alpha-spectrin. The cloned cDNAs will now permit the isolation of the alpha-spectrin gene and should lead to the characterization of the genetic aspects in human hereditary anemias in which alpha-spectrin has been characterized as the site of the molecular defect.

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