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. 1985 Jun;140 ( Pt 4)(Pt 4):607-12.

Effects of chloramphenicol on the long term trophic action of ACTH on rat adrenocortical cells: a combined stereological and enzymological study

G Mazzocchi, G G Nussdorfer

Effects of chloramphenicol on the long term trophic action of ACTH on rat adrenocortical cells: a combined stereological and enzymological study

G Mazzocchi et al. J Anat. 1985 Jun.

Abstract

Chronic chloramphenicol administration was found to block the ACTH-induced increase in both the surface area of mitochondrial cristae and the activity of 11 beta-hydroxylase in zona fasciculata cells of the rat adrenal cortex. The surface area of agranular endoplasmic reticulum membranes and the activity of 3 beta-hydroxysteroid dehydrogenase were not affected by treatment with chloramphenicol. These findings suggest that the mechanism of the ACTH-induced enhancement of the growth and steroidogenic capacity of rat adrenocortical cells involves stimulation of mitochondrial DNA-dependent protein synthesis.

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