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Review
. 2019 Sep 27;20(5):1853-1864.
doi: 10.1093/bib/bby055.

The small peptide world in long noncoding RNAs

Seo-Won Choi  1 , Hyun-Woo Kim  1 , Jin-Wu Nam  1
Affiliations
Review

The small peptide world in long noncoding RNAs

Seo-Won Choi et al. Brief Bioinform. .

Abstract

Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel lncRNAs have been annotated in animal and plant genomes because of advanced high-throughput RNA sequencing technologies and with the aid of coding transcript classifiers. Further, a considerable number of reports have revealed the existence of stable, functional small peptides (also known as micropeptides), translated from lncRNAs. In this review, we discuss the methods of lncRNA classification, the investigations regarding their coding potential and the functional significance of the peptides they encode.

Keywords: coding-potential prediction; long noncoding RNA (lncRNA); small ORF; small peptide.

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Figures

Figure 1.
Figure 1.
Cancer-related lncRNAs with functional peptides. Left side (gray box) of each figure shows the RNA function. (A)LINC00961 related to NSCLC. (B)LINC01420 related to NPC. (C)HOXB-AS3 transcript related to AML in OCI-AML3 cells. The right side (blue box) shows the functions for the peptides. (A) SPAR inhibiting mTORC1 activation. (B) NOBODY promoting NMD in K562 and HEK293T cells. (C) HOXB-AS3 peptide regulating PKM splicing and suppressing cancer growth.
See this image and copyright information in PMC

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