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. 1986 Jan;102(1):88-96.
doi: 10.1083/jcb.102.1.88.

Rates of membrane-associated reactions: reduction of dimensionality revisited

M A McCloskey, M M Poo

Rates of membrane-associated reactions: reduction of dimensionality revisited

M A McCloskey et al. J Cell Biol. 1986 Jan.

Abstract

The hypothesis that reactions associated with intracellular membranes enjoy a kinetic advantage from a reduced dimensionality for diffusion is inconsistent with available data on lateral diffusion rates, membrane-substrate affinities, and endogenous concentrations of enzymes and their aqueous substrates.

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