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. 2018 Jul 16;8(7):e023346.
doi: 10.1136/bmjopen-2018-023346.

Prognostic implications of left ventricular strain by speckle-tracking echocardiography in population-based studies: a systematic review protocol of the published literature

Lamia Al Saikhan  1   2 , Chloe Park  1 , Rebecca Hardy  3 , Alun Hughes  1
Affiliations

Prognostic implications of left ventricular strain by speckle-tracking echocardiography in population-based studies: a systematic review protocol of the published literature

Lamia Al Saikhan et al. BMJ Open. .

Abstract

Introduction: Left ventricular (LV) strain by speckle-tracking echocardiography (STE) is a comparatively new prognostic marker. Meta-analyses relating LV strain by STE to outcomes have been conducted in selected patient-based populations with established or suspected cardiovascular (CV) diseases. However, the evidence related to population-based studies of community-dwelling individuals is uncertain. The aim of this study is to provide a comprehensive systematic review and analysis of the current available literature regarding LV strain by STE as a predictor of adverse outcomes in population-based studies.

Methods and analyses: Thesaurus and text-word searching will be used to search two online databases (MEDLINE and EMBASE) and additional sources will be identified from citation metrics and reference lists' search. Dual search results' screening, data extraction and quality assessment will be performed. Cohort studies of community/population-based samples who have had STE and followed up longitudinally for mortal and morbid events, and published in English and peer-reviewed journals will be included. Primary outcome will be all-cause mortality whereas secondary outcomes will be composite cardiac and CV end points. Risk of bias will be assessed using Newcastle-Ottawa Quality Assessment Scale of cohort studies that will be modified as appropriate. Any arising discrepancies will be discussed and resolved through consensus.

Ethics and dissemination: Ethical approval is not required as this is a protocol for a systematic review. The findings of this study will be presented at scientific conferences and published in a peer-reviewed journal. Any amendments to the protocol will be documented and updated in the PROSPERO registry.

Prospero registration number: CRD42018090302.

Keywords: cardiovascular disease; community dwelling individuals; left ventricular strain; mortality; speckle tracking echocardiography.

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Conflict of interest statement

Competing interests: AH works in a unit that receives support from the UK Medical Research Council (Programme Code MC_UU_12019/1) and also receives support from the British Heart Foundation (PG/15/75/31748, CS/15/6/31468, CS/13/1/30327), and the National Institute for Health Research University College London Hospitals Biomedical Research Centre. CP receives support from the British Heart Foundation (CS/15/6/31468). LA is supported by a scholarship grant from Imam Abdulrahman Bin Faisal University.

Figures

Figure 1
Figure 1
Flow diagram illustrates the study selection process following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.
See this image and copyright information in PMC

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