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. 2018 Nov;32(11):1752-1759.
doi: 10.1038/s41433-018-0151-y. Epub 2018 Jul 16.

Retinopathy of prematurity in the United Kingdom: retreatment rates, visual and structural 1-year outcomes

Gillian Gw Adams  1 , Catey Bunce  1   2 , Wen Xing  1 , Lucilla Butler  3 , Vernon Long  4 , Aravind Reddy  5 , Annegret H Dahlmann-Noor  6 ; UK Retinopathy of Prematurity Special Interest Group
Collaborators, Affiliations

Retinopathy of prematurity in the United Kingdom: retreatment rates, visual and structural 1-year outcomes

Gillian Gw Adams et al. Eye (Lond). 2018 Nov.

Abstract

Aims: To evaluate retreatment rates, visual and anatomical outcomes at 1-year postnatal age in infants treated for retinopathy of prematurity (ROP) METHODS: Longitudinal national surveillance study of infants treated for ROP in the United Kingdom between December 2013 and December 2014, supported by the British Ophthalmic Surveillance Unit. Here we report retreatment rates, anatomical, visual and refractive outcomes at 1-year follow-up.

Results: One-year follow-up forms were completed for 168 children of the original cohort of 327 (51.4%). Twenty-two had at least one retreatment: 17/153 right eyes (REs, 11.1%) after initial diode laser, and 5/14 REs (35.7%) after initial injection of anti-vascular endothelial growth factor (VEGF) antibody. Median (interquartile range) RE best-corrected visual acuity was 0.6 (0.4-1.0) (n = 46 REs), and median acuity both eyes open 0.4 (0.3-0.7) logMAR (n = 89). Median spherical equivalent (RE) was 0.44 (-1.3 to 1.3) dioptre (D) (n = 116). Median astigmatism (RE) was 0.5 (0-1.0) D (n = 111), and median anisometropia 0.125 (0-0.75) D (n = 116). Twenty-four children (20.5%) had been prescribed glasses. Sight impairment certification eligibility information was available for 131 children: 11 (8.4%) were eligible to be certified as sight impaired, and 5 (3.8%) as severely sight impaired.

Conclusions: Retreatment rates are in line with previous reports, and appear higher after initial anti-VEGF antibody than after initial diode laser. Refractive outcomes are in line with previous studies, with a trend towards early emmetropia and myopia following diode laser, particularly in more severe ROP.

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Conflict of interest statement

This work was funded by Moorfields Eye Charity and the Birmingham Eye Foundation. There have not been any financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years and no other relationships or activities that could appear to have influenced the submitted work. The funders have not in any way influenced the study design or conduct, and the researchers are independent from the funders. All authors, external and internal, had full access to all of the data (including statistical reports and tables) in the study and can take responsibility for the integrity of the data and the accuracy of the data analysis. The lead author, AHDN, affirms that the manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned have been explained.

Comment in

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