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. 2018 Jul;43(7):410-429.

Metastatic Soft Tissue Sarcomas: A Review Of Treatment and New Pharmacotherapies

Eric K Singhi, Donald C Moore, Alaa Muslimani

Metastatic Soft Tissue Sarcomas: A Review Of Treatment and New Pharmacotherapies

Eric K Singhi et al. P T. 2018 Jul.

Abstract

Soft tissue sarcomas represent a group of heterogeneous mesenchymal tumors that occur rarely in adults. While a variety of histological subtypes exist, some of the most common are leiomyosarcoma and liposarcoma. For eligible patients, standard first-line treatment of metastatic disease has typically comprised anthracycline-containing regimens. While traditional cytotoxic chemotherapy has been the mainstay of treatment in metastatic soft tissue sarcoma, emerging targeted and novel therapies are creating new frontiers of treatment for a variety of histological subtypes. Olaratumab (Lartruvo, Eli Lilly) in combination with doxorubicin represents a new potential first-line treatment option. Second-line therapy is often histology-driven, and novel treatment options include trabectedin (Yondelis, Janssen) and eribulin (Halaven, Eisai). This review discusses the diagnosis, role of chemotherapy in unresectable and metastatic disease, and role of emerging therapies in the treatment of metastatic soft tissue sarcoma.

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Conflict of interest statement

Disclosures: The authors report no commercial or financial interests in regard to this article.

Figures

Figure 1
Figure 1
Incidence of Most Common Adult Soft Tissue Sarcoma Histologies (%)
See this image and copyright information in PMC

References

    1. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO Classification of Tumours of Soft Tissue and Bone. 4th ed. Lyon, France: IARC Press, International Agency for Research on Cancer; 2013.
    1. Siegel RL, Miller KD, Jermal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7–30. - PubMed
    1. Vezeridis MP, Moore R, Karakousis CP. Metastatic patterns in soft-tissue sarcomas. Arch Surg. 1983;118:915–918. - PubMed
    1. Potter DA, Glenn J, Kinsella T, et al. Patterns of recurrence in patients with high-grade soft-tissue sarcomas. J Clin Oncol. 1985;3:353–366. - PubMed
    1. Vogt-Moykopf I, Bülzebruck H, Merkle NM, et al. Results of surgical treatment of pulmonary metastases. Eur J Cardiothorac Surg. 1988;2:224–232. - PubMed