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Case Reports
. 2018 Jun 14:2018:7591709.
doi: 10.1155/2018/7591709. eCollection 2018.

Herpes Simplex Virus Colitis in a Patient with Newly Diagnosed Crohn's Disease

H Jafri  1 , D R Kalina  2 , T Aziz  3 , P E Serrano  4 , S Haider  1   2
Affiliations
Case Reports

Herpes Simplex Virus Colitis in a Patient with Newly Diagnosed Crohn's Disease

H Jafri et al. Case Rep Med. .

Abstract

Herpesvirus colitis is a known cause of morbidity and mortality amongst immunosuppressed individuals. We present a case of HSV colitis following a diagnosis of Crohn's Disease and methylprednisolone therapy. Diagnosis was confirmed by immunohistochemical staining and supported by polymerase chain reaction (PCR) of cutaneous vesicles. The patient recovered following three weeks of acyclovir.

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Figures

Figure 1
Figure 1
(a) Section from the ulcerated colonic mucosa with deep fissuring ulcer. Viral cytopathic changes are noted. (b, c) Giant cells within ulcer with characteristic intranuclear Cowdry type A inclusions of HSV-1 and HSV-2. Black arrows point to individual giant cells with Cowdry type A inclusions. (d) Immunohistochemistry study for HSV-2 antibody highlighted by the brown nuclear staining.
See this image and copyright information in PMC

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