Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Nov;29(11):2369-2387.
doi: 10.1007/s00198-018-4618-2. Epub 2018 Jul 16.

Phosphate wasting disorders in adults

G Marcucci  1 , L Masi  1 , S Ferrarì  2 , D Haffner  3 , M K Javaid  4 , P Kamenický  5 , J-Y Reginster  6 , R Rizzoli  2 , M L Brandi  7
Affiliations
Review

Phosphate wasting disorders in adults

G Marcucci et al. Osteoporos Int. 2018 Nov.

Abstract

A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the FGF-23 pathway. This review focuses on phosphate metabolism, its main regulators, and phosphate wasting disorders in adults, highlighting the main issues related to diagnosis and current and new potential treatments.

Keywords: FGF-23; Hypophosphatemia; Osteomalacia; Phosphate wasting disorders; Rickets; Treatment.

PubMed Disclaimer

References

    1. Manghat P, Sodi R, Swaminathan R (2014) Phosphate homeostasis and disorders. Ann Clin Biochem 51:631–656 - DOI
    1. Demay MB, Sabbagh Y, Carpenter TO (2007) Calcium and vitamin D: what is known about the effects on growing bone. Pediatrics 119:141–144 - DOI
    1. Fukumoto S (2014) Phosphate metabolism and vitamin D. Bonekey Rep 3:497–502 - PubMed - PMC
    1. Pavone V, Testa G, Gioitta Iachino S, Evola FR, Avondo S, Sessa G (2015) Hypophosphatemic rickets: etiology, clinical features and treatment. Eur J Orthop Surg Traumatol 25:221–226 - DOI
    1. Segawa H, Kaneko I, Yamanaka S, Ito M, Kuwahata M, Inoue Y, Kato S, Miyamoto KI (2004) Intestinal Na-P(i) cotransporter adaptation to dietary P(i) content in vitamin D receptor null mice. Am J Physiol Renal Physiol 287:F39–F47 - DOI

MeSH terms

LinkOut - more resources