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. 2018 Sep;67(9):1217-1220.
doi: 10.1099/jmm.0.000801. Epub 2018 Jul 17.

In vitro activity of β-lactams in combination with avibactam against multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Achromobacter xylosoxidans isolates from patients with cystic fibrosis

Vincent Mathy  1 , Patrick Grohs  1 , Fabrice Compain  1   2
Affiliations

In vitro activity of β-lactams in combination with avibactam against multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Achromobacter xylosoxidans isolates from patients with cystic fibrosis

Vincent Mathy et al. J Med Microbiol. 2018 Sep.

Abstract

The in vitro activity of anti-pseudomonal β-lactams in combination with avibactam was evaluated against 54 multidrug-resistant non-fermenting Gram-negative bacilli isolated from cystic fibrosis patients. Avibactam increased and/or restored the antibacterial activities of ceftazidime and aztreonam against Pseudomonas aeruginosa and Stenotrophomonas maltophilia, respectively. No β-lactam-avibactam combination was active against Achromobacter xylosoxidans.

Keywords: Achromobacter; Pseudomonas; Stenotrophomonas; avibactam; cystic fibrosis; β-lactam.

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