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. 2018 Jul 16;46(2):128-130.
doi: 10.1016/j.devcel.2018.06.021.

The Domino Effect in EGFR-ERK Signaling

Udi Binshtok  1 , David Sprinzak  2
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The Domino Effect in EGFR-ERK Signaling

Udi Binshtok et al. Dev Cell. .
Free article

Abstract

A gradient of EGFR-ERK signaling has been classically implicated in various developmental processes. In this issue of Developmental Cell, Ogura et al. (2018) show that in the Drosophila tracheal placode, EGFR-ERK signaling propagates via a cell-by-cell relay mechanism rather than a gradient, and this sequential ERK activation controls proper placode invagination.

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