Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jan;83(2):470-3.
doi: 10.1073/pnas.83.2.470.

Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma

J Trent, P Meltzer, M Rosenblum, G Harsh, K Kinzler, R Mashal, A Feinberg, B Vogelstein

Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma

J Trent et al. Proc Natl Acad Sci U S A. 1986 Jan.

Abstract

Amplified cellular genes are frequently manifested in one of two cytologically recognizable forms, double minutes or homogeneously staining regions. Additionally, evidence is accumulating that aberrant expression of cellular genes (including oncogenes) may be mediated by gene amplification. We now describe the amplification and expression of the cellular oncogene c-myc in double-minute-containing cells from a patient with glioblastoma multiforme, and we have shown that the amplification is associated with rearrangement of the c-myc gene. This finding further supports the common association of the myc gene family in neurogenic tumors and provides evidence of myc gene amplification in human brain cancer.

PubMed Disclaimer

References

    1. Mol Cell Biol. 1983 Nov;3(11):2076-88 - PubMed
    1. Annu Rev Biochem. 1983;52:301-54 - PubMed
    1. Nature. 1984 Mar 15-21;308(5956):288-91 - PubMed
    1. Science. 1984 Jun 8;224(4653):1121-4 - PubMed
    1. J Biol Chem. 1984 Jul 25;259(14):9127-40 - PubMed

Publication types

LinkOut - more resources