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Comment
. 2018 Sep;24(9):731-733.
doi: 10.1016/j.molmed.2018.06.010. Epub 2018 Jul 17.

CRISPR: Stressed about p53?

Miguel Foronda  1 , Lukas E Dow  2
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Comment

CRISPR: Stressed about p53?

Miguel Foronda et al. Trends Mol Med. 2018 Sep.

Abstract

Two recent reports show that, in some contexts, CRISPR-mediated genome editing can lead to a p53-mediated stress response and cell-cycle arrest. These findings may help to explain why CRISPR-mediated genetic manipulation in different cell types leads to dissimilar outcomes, and highlights the need for a better understanding of the factors that influence effective genome editing in vitro and in vivo.

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