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Review
. 2018 Jul;4(4):503-505.
doi: 10.1016/j.euf.2018.07.005. Epub 2018 Jul 14.

Combination Intravesical Chemotherapy for Non-muscle-invasive Bladder Cancer

Ryan L Steinberg  1 , Lewis J Thomas  1 , Michael A O'Donnell  2
Affiliations
Review

Combination Intravesical Chemotherapy for Non-muscle-invasive Bladder Cancer

Ryan L Steinberg et al. Eur Urol Focus. 2018 Jul.

Abstract

Bacillus Calmette-Guérin (BCG) replaced early intravesical chemotherapeutic agents as the standard of care for non-muscle-invasive bladder cancer (NMIBC) with its US Food and Drug Administration approval in 1990. Multiple studies have proven the superiority of BCG to surgery alone, and to older single-agent intravesical chemotherapy regimens. However, new multiagent intravesical chemotherapy regimens have been developed and tested in recent years. Such regimens offer the possibility of better efficacy and/or tolerability compared to BCG. However, high-quality data comparing such regimens to BCG remain scant. We briefly review the literature regarding combination intravesical chemotherapy for NMIBC.

Keywords: Chemotherapy; Combination therapy; Intravesical therapy; Non–muscle-invasive bladder cancer.

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