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. 2019 Feb 1;68(4):684-687.
doi: 10.1093/cid/ciy565.

Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Jens Verheyen  1   2 , Alexander Thielen  2 , Nadine Lübke  3 , Miriam Dirks  1 , Marek Widera  1 , Ulf Dittmer  1 , Lambros Kordelas  4 , Martin Däumer  2 , Dorien C M de Jong  5 , Annemarie M J Wensing  5 , Rolf Kaiser  6 , Monique Nijhuis  5 , Stefan Esser  7
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Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Jens Verheyen et al. Clin Infect Dis. .

Abstract

Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

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