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Lymphoplasmacytic lymphoma, or Waldenstrom macroglobulinemia, is a low-grade B cell lymphoproliferative neoplasm characterized by small lymphocytes and monoclonal IgM monoclonal gammopathy. The disorder presents with symptoms related to bone marrow infiltration and IgM monoclonal gammopathy. Lymphoplasmacytic lymphoma is a diagnosis of exclusion; a diagnosis should only be rendered after the exclusion of all other small B cell lymphomas. Waldenstrom macroglobulinemia was described in 1944 by Jan G. Waldenstrom, who reported an unusual presentation of lymphadenopathy bleeding, anemia, elevated sedimentation rate, hyperviscosity, and hypergammaglobulinemia in two patients.
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