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Comment
. 2018 Jul 17;49(1):6-8.
doi: 10.1016/j.immuni.2018.06.013.

Viral Infection "Interferes" with Glucose Tolerance

Kaitlin Kiernan  1 , Nancie J MacIver  2
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Free article
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Viral Infection "Interferes" with Glucose Tolerance

Kaitlin Kiernan et al. Immunity. .
Free article

Abstract

In this issue of Immunity, Šestan et al. (2018) show that viral-induced inflammation leads to insulin resistance in skeletal muscle, followed by compensatory hyperinsulinemia, which promotes the anti-viral effector response of CD8+ T cells. Interestingly, this leads to persistent glucose intolerance and the progression of type 2 diabetes in pre-diabetic animals.

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