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. 1985:190:479-93.
doi: 10.1007/978-1-4684-7853-2_24.

Extrachromosomal circular DNA and aging cells

C K Lumpkin Jr, J R McGill, K T Riabowol, E J Moerman, R J Shmookler Reis, S Goldstein

Extrachromosomal circular DNA and aging cells

C K Lumpkin Jr et al. Adv Exp Med Biol. 1985.

Abstract

A DNA sequence situated in the human genome between Alu-repeat clusters ("Inter-Alu" DNA) is progressively amplified in extrachromosomal DNA, including covalently closed DNA circles, during serial passage of diploid fibroblasts. A single size-class of Inter-Alu circles is also amplified in lymphocytes from 16 of 24 old donors and yet is not detected in cells from 18 young donors.

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