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. 1986;87(1-2):143-50.
doi: 10.1007/BF01310551.

Persistent infection of rat insulinoma cells with Coxsackie B4 virus. Brief report

J A Frank Jr, E V Schmidt, R E Smith, C M Wilfert

Persistent infection of rat insulinoma cells with Coxsackie B4 virus. Brief report

J A Frank Jr et al. Arch Virol. 1986.

Abstract

Plaque purified Coxsackie B4 virus (CB4) caused a persistent infection of rat insulinoma (RIN) cells which lasted for the 70 day observation period. Infectious virus was produced and no cytopathic effect was observed. Indirect immunofluorescence and infectious center assays demonstrated that a majority of RIN cells were infected. Defective interfering particles were not demonstrated. Despite persistent infection, insulin synthesis by RIN cells was not altered.

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References

    1. Br Med J. 1973 Nov 3;4(5887):260-2 - PubMed
    1. Postgrad Med J. 1974 Aug;50 Suppl 3:538-43 - PubMed
    1. Appl Microbiol. 1972 Jan;23(1):54-61 - PubMed
    1. Infect Immun. 1981 Feb;31(2):646-9 - PubMed
    1. J Pediatr. 1975 Apr;86(4):654-6 - PubMed

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