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. 2018 Jun;9(3):105-111.
doi: 10.24171/j.phrp.2018.9.3.04.

How Should Biobanks Collect Biosamples for Clinical Application? A 20-year Biomarker-related Publication and Patent Trend Analysis

Jae-Eun Lee  1
Affiliations

How Should Biobanks Collect Biosamples for Clinical Application? A 20-year Biomarker-related Publication and Patent Trend Analysis

Jae-Eun Lee. Osong Public Health Res Perspect. 2018 Jun.

Abstract

Objectives: This study was designed to analyze biomarker-related publications and patent trends which biobanks could consider in planning biosample collections for biomarker research.

Methods: Publications and patents containing the term "biomarker" in the title published between 1998 to 2017 were retrieved using Scopus database and Google Patents search engine.

Results: Over the last 20 years there has been a steady increase in biomarker-related publications and patents; however this has slowed for patents over the last few years. Publications in 2017 that contained blood, serum, and plasma search terms in the abstract accounted for 50%, and serum as a search term in the title and abstract was more numerous than those containing blood, plasma, tissue, or urine. Blood-related patents were the most common patent in the last 10 years, and accounted for 110 patents in 2017. Biomarker-related publications since 2010 containing RNA and protein search terms in the title and abstract, were more numerous than those containing DNA and metabolite search terms. More than 27% of biomarker-related publications in 2017 and 21% of biomarker-related patents were associated with cancer.

Conclusion: The results of this study will help biobanks establish a biosample collection strategy for clinical application.

Keywords: biomarkers; patent; publication; trends.

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Conflict of interest statement

Conflicts of Interest The author declares that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Annual number of publications containing the term “biomarker” in the title which published from 1998 to 2017.
Figure 2
Figure 2
Publications containing various biosample search terms in (A) the title, (B) the abstract. These were extracted from the biomarker-related publications.
Figure 3
Figure 3
Literature containing various analyte search terms in the title (A) and abstract (B). These were extracted from the biomarker-related publications.
Figure 4
Figure 4
Publications containing RNA and microRNA search terms in the abstract. These were extracted from the biomarker-related publications.
Figure 5
Figure 5
Literature containing search terms related to biomarker discovery purposes in the title (A) and abstract (B). These were extracted from the biomarker-related publications.
Figure 6
Figure 6
Annual number of patents containing the term “biomarker” in the title which published from 1998 to 2017.
Figure 7
Figure 7
Annual number of patents related to blood, serum, plasma, tissue, and urine (A) and cancer-related patents published in 2017 (B). These were extracted from the biomarker-related patents.
See this image and copyright information in PMC

References

    1. Niklinski J, Kretowski A, Moniuszko M, et al. Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy: The Polish MOBIT project. Adv Med Sci. 2017;62(2):405–13. doi: 10.1016/j.advms.2017.05.002. - DOI - PubMed
    1. Armand-Labit V, Pradines A. Circulating cell-free microRNAs as clinical cancer biomarkers. Biomol Concepts. 2017;8(2):61–81. doi: 10.1515/bmc-2017-0002. - DOI - PubMed
    1. Cheng X, Zhang L, Chen Y, et al. Circulating cell-free DNA and circulating tumor cells, the “liquid biopsies” in ovarian cancer. J Ovarian Res. 2017;10(1):75. doi: 10.1186/s13048-017-0369-5. - DOI - PMC - PubMed
    1. Havelund JF, Heegaard NHH, Færgeman NJK, et al. Biomarker Research in Parkinson’s Disease Using Metabolite Profiling. Metabolites. 2017;7(3) doi: 10.3390/metabo7030042. pii: E42. - DOI - PMC - PubMed
    1. Zamay TN, Zamay GS, Kolovskaya OS, et al. Current and Prospective Protein Biomarkers of Lung Cancer. Cancers (Basel) 2017;9(11) doi: 10.3390/cancers9110155. pii: E155. - DOI - PMC - PubMed