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. 2018 May 12:15:135-136.
doi: 10.1016/j.ymgmr.2018.05.001. eCollection 2018 Jun.

Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease

Juan F Calderón  1 , Andrés D Klein  1
Affiliations

Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease

Juan F Calderón et al. Mol Genet Metab Rep. .
No abstract available

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Figures

Fig. 1
Fig. 1
Rapamycin exerts opposite effects on NPC mice depending on their genetic background. Kaplan-Meier survival curves (in days) of Npc1−/− mice from the C57 (A) and FVB (B) genetic backgrounds daily i.p. injected with Mock (solid lines) or Rapamycin (Rapa) (10 mg/kg) (dashed lines). Significant differences in survival curves were determined by Log-rank (Mantel–Cox) analyses. Values were considered statistically significantly different when p ≤ 0.05. Animal studies are in compliance with regulations set by our Institutional Animal Care and Use Committee.
See this image and copyright information in PMC

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