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Case Reports
. 2018 Jun 2;4(6):524-527.
doi: 10.1016/j.jdcr.2018.05.002. eCollection 2018 Jul.

Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome

Ines Kerneuzet  1 , Eline Blind  1 , Laure Darrieux  1 , Stéphanie Moreau  2 , Gilles Safa  1
Affiliations
Case Reports

Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome

Ines Kerneuzet et al. JAAD Case Rep. .
No abstract available

Keywords: DRESS, drug reaction with eosinophilia and systemic symptoms; RegiSCAR, European Registry of Severe Cutaneous Adverse Reactions; SCAR, severe cutaneous adverse reactions; SJS, Stevens Johnson syndrome; TEN, toxic epidermal necrolysis; drug reaction; drug reaction with eosinophilia and systemic symptoms; ivermectin.

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Figures

Fig 1
Fig 1
DRESS syndrome 2 weeks after starting ivermectin treatment. A, Facial edema. B, Close-up view of erythematous, edematous, and exfoliative dermatitis on the thigh.
Fig 2
Fig 2
Histopathology of lesional abdominal skin. A, Low power. Consistent with drug hypersensitivity reaction, this biopsy shows mild spongiosis with a vesicle and superficial perivascular lymphocytic infiltrate with eosinophils. B, High power. Numerous eosinophils. (Hematoxylin-eosin stain; original magnifications: A, ×100; B, ×400.)
See this image and copyright information in PMC

References

    1. Husain Z., Reddy B.Y., Schwartz R.A. DRESS syndrome: Part I. Clinical perspectives. J Am Acad Dermatol. 2013;68:693. e1-e14. - PubMed
    1. Kardaun S.H., Sekula P., Valeyrie-Allanore L. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol. 2013;169:1071–1080. - PubMed
    1. Kardaun S.H., Sidoroff A., Valeyrie-Allanore L. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol. 2007;155:609–611. - PubMed
    1. Roujeau J.C., Allanore L., Liss Y., Mockenhaupt M. Severe cutaneous adverse reactions to drugs (SCAR): definitions, diagnostic criteria, genetic predisposition. Dermatol Sinica. 2009;27:203–209.
    1. Seishima M., Yamanaka S., Fujisawa T., Tohyama M., Hashimoto K. Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome. Br J Dermatol. 2006;155:344–349. - PubMed

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