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Review
. 2018;14(12):3010-3018.
doi: 10.1080/21645515.2018.1496878. Epub 2018 Sep 11.

Should human papillomavirus vaccination target women over age 26, heterosexual men and men who have sex with men? A targeted literature review of cost-effectiveness

Affiliations
Review

Should human papillomavirus vaccination target women over age 26, heterosexual men and men who have sex with men? A targeted literature review of cost-effectiveness

Nyi Nyi Soe et al. Hum Vaccin Immunother. 2018.

Abstract

Background: Human papillomavirus (HPV) vaccination for young women up to age 26 is highly cost-effective and has been implemented in 65 countries globally. We investigate the cost-effectiveness for HPV vaccination program in older women (age > 26 years), heterosexual men and men who have sex with men (MSM).

Method: A targeted literature review was conducted on PubMed for publications between January 2000 and January 2017 according to the PRISMA guidelines. We included English-language articles that reported the incremental cost-effectiveness ratio (ICER) of HPV vaccination programs for women over age 26, heterosexual men, and MSM and identified the underlying factors for its cost-effectiveness.

Results: We included 36 relevant articles (six, 26 and four in older women, heterosexual men and MSM, respectively) from 17 countries (12 high-income (HICs) and five low- and middle-income (LMICs) countries). Most (4/6) studies in women over age 26 did not show cost-effectiveness ($65,000-192,000/QALY gained). Two showed cost-effectiveness, but only when the vaccine cost was largely subsidised and protection to non-naïve women was also considered. Sixteen of 26 studies in heterosexual men were cost-effective (ICER = $19,600-52,800/QALY gained in HICs; $49-5,860/QALY gained in LMICs). Nonavalent vaccines, a low vaccine price, fewer required doses, and a long vaccine protection period were key drivers for cost-effectiveness. In contrast, all four studies on MSM consistently reported cost-effectiveness (ICER = $15,000-$43,000/QALY gained), particularly in MSM age < 40 years and those who were HIV-positive. Countries' vaccination coverage did not significantly correlate with its per-capita Gross National Income.

Conclusion: Targeted HPV vaccination for MSM should be next priority in HPV prevention after having established a solid girls vaccination programme. Vaccination for heterosexual men should be considered when 2-dose 4vHPV/9vHPV vaccines become available with a reduced price, whereas targeted vaccination for women over age 26 is unlikely to be cost-effective.

Keywords: Human papillomavirus; cost-effectiveness; men who have sex with men; vaccine.

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Figures

Figure 1.
Figure 1.
Selection of papers with PRISMA Statement.
Figure 2.
Figure 2.
Cost-effectiveness of included studies for women (> 26yr), heterosexual men and MSM.

References

    1. Walboomers JMM, Jacobs MV, Mnos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJF, Peto J, Meijer CJLM, Munoz N.. Human Papillomavirus is a necessary cause of invasive cervical cancer worldwide. 1999; Sep;189(1):12-9. - PubMed
    1. Centers for Disease Control and Prevention HPV and men- CDC fact sheet. 2015. February https://www.cdc.gov/std/hpv/hpv-and-men-factsheet-feb-2015.pdf.
    1. World Health Organization Cervical cancer. 2018. http://www.who.int/cancer/prevention/diagnosis-screening/cervical-cancer....
    1. World Health Organization Human papillomavirus (HPV) and cervical cancer. 2016. June http://www.who.int/mediacentre/factsheets/fs380/en/.
    1. World Health Organization Safety update of HPV vaccines. 2017. accessed http://www.who.int/vaccine_safety/committee/topics/hpv/June_2017/en/.

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