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. 2018 Dec;38(12):2134-2136.
doi: 10.1111/liv.13934. Epub 2018 Aug 10.

Regression of hepatocellular adenoma after bariatric surgery in severe obese patients

Tom J G Gevers  1 , B W Marcel Spanier  1 , Peter B Veendrick  2 , Jan Maarten Vrolijk  1
Affiliations

Regression of hepatocellular adenoma after bariatric surgery in severe obese patients

Tom J G Gevers et al. Liver Int. 2018 Dec.

Abstract

Background & aim: Obesity and metabolic syndrome are increasingly recognized as risk factors for hepatocellular adenomas (HCA). There is still sparse evidence whether weight loss or bariatric surgery could induce HCA regression in these patients. In this brief report we describe the effect of weight loss on HCA regression in severe obese patients that had undergone bariatric surgery in our centre.

Methods: We performed an Electronic Patient Database search and included all patients who underwent bariatric surgery in our bariatric referral centre and had an ICD-10 code of benign neoplasm of liver in our centre from (2006-2017). All imaging studies of eligible patients were re-evaluated by the study radiologist. Primary outcome was change in maximal diameter of HCA.

Results: Six of 11 eligible patients were excluded because their lesions were classified as probable focal nodular hyperplasia and two were lost to follow-up. Finally, three women with solitary (n = 1) or multiple HCA (n = 2) and a body mass index (BMI) ranging between 39 and 50 kg/m2 were included. In two patients, HCA completely regressed in 1-2 years following bariatric surgery, after BMI reductions of 36%-48%. The third patient showed a reduction of >50% in diameter of the largest HCA in 2.5 years after bariatric surgery (31% BMI reduction), with complete resolution of smaller HCA.

Conclusions: Bariatric induced weight loss results in significant regression of HCA in severe obese women, which emphasizes the role of overweight in HCA pathophysiology.

Keywords: liver adenoma; non-alcoholic fatty liver disease; obesity; roux-and-y gastric bypass.

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