Observational Study

. 2018 Jul 19;18(1):237.

doi: 10.1186/s12887-018-1208-6.

The CANadian Pediatric Weight management Registry (CANPWR): lessons learned from developing and initiating a national, multi-centre study embedded in pediatric clinical practice

Katherine M Morrison^{1

2}, Geoff D C Ball³, Josephine Ho⁴, Pam Mackie⁵, Annick Buchholz⁶, Jean-Pierre Chanoine⁷, Jill Hamilton⁸, Anne-Marie Laberge⁹, Laurent Legault¹⁰, Lehana Thabane^{11

5}, Mark Tremblay⁶, Ian Zenlea¹²

Affiliations

¹ Department of Pediatrics, McMaster University, Hamilton, ON, Canada. kmorrison@mcmaster.ca.
² Population Health Research Institute, McMaster University, Hamilton, ON, Canada. kmorrison@mcmaster.ca.
³ Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
⁴ Department of Pediatrics, University of Calgary, Calgary, AB, Canada.
⁵ Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
⁶ Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
⁷ Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
⁸ The Hospital for Sick Children, Toronto, ON, Canada.
⁹ Department of Pediatrics, CHU Ste Justine, Montreal, QC, Canada.
¹⁰ Department of Pediatrics, McGill University, Montreal, QC, Canada.
¹¹ Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
¹² Credit Valley Hospital, Mississauga, ON, Canada.

PMID: 30025530
PMCID: PMC6053829
DOI: 10.1186/s12887-018-1208-6

Observational Study

The CANadian Pediatric Weight management Registry (CANPWR): lessons learned from developing and initiating a national, multi-centre study embedded in pediatric clinical practice

Katherine M Morrison et al. BMC Pediatr. 2018.

. 2018 Jul 19;18(1):237.

doi: 10.1186/s12887-018-1208-6.

Authors

Affiliations

¹ Department of Pediatrics, McMaster University, Hamilton, ON, Canada. kmorrison@mcmaster.ca.
² Population Health Research Institute, McMaster University, Hamilton, ON, Canada. kmorrison@mcmaster.ca.
³ Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
⁴ Department of Pediatrics, University of Calgary, Calgary, AB, Canada.
⁵ Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
⁶ Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
⁷ Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
⁸ The Hospital for Sick Children, Toronto, ON, Canada.
⁹ Department of Pediatrics, CHU Ste Justine, Montreal, QC, Canada.
¹⁰ Department of Pediatrics, McGill University, Montreal, QC, Canada.
¹¹ Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
¹² Credit Valley Hospital, Mississauga, ON, Canada.

PMID: 30025530
PMCID: PMC6053829
DOI: 10.1186/s12887-018-1208-6

Abstract

Background: There is increasing recognition of the value of "real-world evidence" in evaluating health care services. Registry-based, observational studies conducted in clinical settings represent a relevant model to achieve this directive. Starting in 2010, we undertook a longitudinal, observational study (the CANadian Pediatric Weight management Registry [CANPWR]), which is embedded in 10 multidisciplinary, pediatric weight management clinics across Canada. The objective of this paper was to share the lessons our team learned from this multi-centre project.

Methods: Data sources included a retrospective review of minutes from 120 teleconferences with research staff and investigators, notes taken during clinical site visits made by project leaders, information from quality control processes to ensure data accuracy and completeness, and a study-specific survey that was sent to all sites to solicit feedback from research team members (n = 9). Through an iterative process, the writing group identified key themes that surfaced during review of these information sources and final lessons learned were developed.

Results: Several key lessons emerged from our research, including the (1) value of pilot studies and central research coordination, (2) need for effective and regular communication, (3) importance of consensus on determining outcome measures, (4) challenge of embedding research within clinical practice, and (5) difficulty in recruiting and retaining participants. The sites were, in spite of these challenges, enthusiastic about the benefits of participating in multi-centre collaborative studies.

Conclusion: Despite some challenges, multi-centre observational studies embedded in pediatric weight management clinics are feasible and can contribute important, practical insights into the effectiveness of health services for managing pediatric obesity in real-world settings.

Keywords: Cardiometabolic health outcomes; Childhood obesity; Cohort study; Pediatric; Research methodology; Treatment; Weight management.

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Conflict of interest statement

Ethics approval and consent to participate

The CANPWR study was approved by the following Research Ethics Boards: Hamilton Integrated Research Ethics Board, Conjoint Health Research Ethics Board (Calgary, Alberta), Research Ethics Board Trillium Health Partners, Health Research Ethics Board - Health Panel (Edmonton, Alberta), Children’s Hospital of Eastern Ontario Research Ethics Board, The Hospital for Sick Children Research Ethics Board, University of British Columbia Clinical Research Ethics Board, CHU Sainte-Justine Research Ethics Board, McGill University Health Centre Research Ethics Board – Pediatrics.

Written consent was received from the legal guardian of each study participant (all under 18 years of age). In addition, children age 5–17 years provided assent (a common practice with Canadian Children’s Hospital Research Ethics Boards).

Consent for publication

Not applicable.

Competing interests

KM Morrison – No competing financial interests exist.

GDC Ball – No competing financial interests exist.

J Ho – No competing financial interests exist.

P Mackie – No competing financial interests exist.

I Zenlea – No competing financial interests exist.

A Buchholz – No competing financial interests exist.

JP Chanoine – No competing financial interests exist.

M Tremblay – No competing financial interests exist.

J Hamilton – Recipient of unrestricted research funds from the SickKids University of Toronto Mead Johnson Chair in Child Nutritional Science.

AM Laberge – No competing financial interests exist.

L Legault – No competing financial interests exist.

L Thabane – No competing financial interests exist.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

1. Peirson L, Fitzpatrick-Lewis D, Morrison K, Warren R, Usman Ali M, Raina P. Treatment of overweight and obesity in children and youth: a systematic review and meta-analysis. CMAJ Open. 2015;3:E35–E46. doi: 10.9778/cmajo.20140047. - DOI - PMC - PubMed
1. Wilfley DE, Staiano AE, Altman M, et al. Improving access and systems of care for evidence-based childhood obesity treatment: conference key findings and next steps. Obesity (Silver Spring) 2017;25:16–29. doi: 10.1002/oby.21712. - DOI - PMC - PubMed
1. Morrison KM, Damanhoury S, Buchholz A, et al. The CANadian pediatric weight management registry (CANPWR): study protocol. BMC Pediatr. 2014;14:161. doi: 10.1186/1471-2431-14-161. - DOI - PMC - PubMed
1. Tremblay MS, Feng M, Garriguet D, et al. Canadian pediatric weight management registry (CANPWR): baseline descriptive statistics and comparison to Canadian norms. BMC Obes. 2015;2:29. doi: 10.1186/s40608-015-0060-6. - DOI - PMC - PubMed
1. Hoque DME, Kumari V, Ruseckaite R, et al. Impact of clinical registries on quality of patient care and health outcomes: protocol for a systematic review. BMJ Open. 2016;6:e010654. doi: 10.1136/bmjopen-2015-010654. - DOI - PMC - PubMed

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The CANadian Pediatric Weight management Registry (CANPWR): lessons learned from developing and initiating a national, multi-centre study embedded in pediatric clinical practice

Affiliations

The CANadian Pediatric Weight management Registry (CANPWR): lessons learned from developing and initiating a national, multi-centre study embedded in pediatric clinical practice

Authors

Affiliations

Abstract

Conflict of interest statement

Ethics approval and consent to participate

Consent for publication

Competing interests

Publisher’s Note

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases