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Comment
. 2018 Aug 6;215(8):1967-1969.
doi: 10.1084/jem.20181152. Epub 2018 Jul 19.

Eosinophils can more than kill

Claudia Berek  1
Affiliations
Free PMC article
Comment

Eosinophils can more than kill

Claudia Berek. J Exp Med. .
Free PMC article

Abstract

In this issue of JEM, Arnold et al. (https://doi.org/10.1084/jem.20172049) demonstrate that eosinophils suppress mucosal inflammation by directly interacting with pro-inflammatory Th1 cells. This emphasizes the dual role of eosinophils, which can act both as effector cells that control an infection and as immunomodulatory cells that promote immune homeostasis.

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Figures

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Insight from Claudia Berek.
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The role of mucosal eosinophils. In the presence of activated eosinophils, Th1 cells down-regulate (↓) cytokine expression. Peyer’s patches (PP) and lamina propria (LP) are indicated.
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Pathways of eosinophil activation and differentiation.
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Comment on

References

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