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Comment
. 2018 Jul 20;361(6399):226-227.
doi: 10.1126/science.aau4385.

Transcriptional control of kidney cancer

Danielle J Sanchez  1   2 , M Celeste Simon  3   2
Affiliations
Comment

Transcriptional control of kidney cancer

Danielle J Sanchez et al. Science. .
No abstract available

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Figures

Figure 1.
Figure 1.. The novel pVHL substrate ZHX2 promotes NF-kB gene expression and tumorigenesis in ccRCC
ZHX2 escapes proteasomal degradation in VHL-deficient ccRCC and accumulates in the nucleus, where it binds to NF-κB consensus motifs on DNA along with p65/RelA. Genetic depletion of ZHX2 reduces nuclear accumulation of p65, NF-κB target gene expression, and tumor growth.
See this image and copyright information in PMC

Comment on

  • VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
    Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG Jr, Baldwin AS, Zhang Q. Zhang J, et al. Science. 2018 Jul 20;361(6399):290-295. doi: 10.1126/science.aap8411. Science. 2018. PMID: 30026228 Free PMC article.

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