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Case Reports
. 2018 Jun 20:2018:5931046.
doi: 10.1155/2018/5931046. eCollection 2018.

A Case of Atorvastatin-Associated Necrotizing Autoimmune Myopathy, Mimicking Idiopathic Polymyositis

Ayushi Dixit  1 , Adriana Abrudescu  1
Affiliations
Case Reports

A Case of Atorvastatin-Associated Necrotizing Autoimmune Myopathy, Mimicking Idiopathic Polymyositis

Ayushi Dixit et al. Case Rep Rheumatol. .

Abstract

Statin-induced necrotizing autoimmune myopathy (SINAM) is a rare side effect of statin use which manifests as progressive muscle weakness. Because statins are a widely prescribed medication for coronary artery disease, hyperlipidemia, and many other diseases, many patients are at risk of developing SINAM or one of the many other statin-induced myopathies. Due to identification of an antibody specific to this disease, we were able to diagnose SINAM in a patient whose symptoms had progressed to the extent that they were debilitating. Our case describes SINAM in a patient undergoing treatment with a statin for an extended period of time, diagnosis of the disease process, treatment, and resolution of symptoms.

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Figures

Figure 1
Figure 1
Surgical pathology report.
Figure 2
Figure 2
Microscopic right quadriceps muscle biopsy showing necrotic muscle fibers and regenerating fibers. (a) Arrow pointing at necrotic muscle fiber (magnification 20x with alkaline phosphatase stain). (b) Arrow pointing at regenerating muscle fiber (magnification 20x with alkaline phosphatase stain).
See this image and copyright information in PMC

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