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. 2018 Oct 1:188:107-110.
doi: 10.1016/j.talanta.2018.05.065. Epub 2018 May 22.

Homoarsenocholine - A novel arsenic compound detected for the first time in nature

Simone Braeuer  1 , Jan Borovička  2 , Toma Glasnov  1 , Gema Guedes de la Cruz  1 , Kenneth B Jensen  1 , Walter Goessler  3
Affiliations

Homoarsenocholine - A novel arsenic compound detected for the first time in nature

Simone Braeuer et al. Talanta. .

Abstract

The arsenic speciation was determined in macrofungi of the Ramaria genus with HPLC coupled to inductively coupled plasma mass spectrometry. Besides arsenic species that are already known for macrofungi, like arsenobetaine or arsenocholine, two compounds that were only known from marine samples so far (trimethylarsoniopropanate and dimethylarsinoylacetate) were found for the first time in a terrestrial sample. An unknown arsenical was isolated and identified as homoarsenocholine. This could be a key intermediate for further elucidation of the biotransformation mechanisms of arsenic.

Keywords: (3-hydroxypropyl) trimethylarsonium ion; Arsenic speciation; Fungi; Homoarsenocholine; ICPMS; Ramaria.

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Conflict of interest statement

Conflict of interest

None.

Figures

Fig. 1
Fig. 1
Exemplary anion-exchange (a) and cation-exchange (b) chromatograms of a Ramaria extract. Dotted line: extract spiked with TMAO, TMAP, AC, TETRA and UNK A (= AC2).
Fig. 2
Fig. 2
Mass spectrum of HR ES-MS of UNK A (AC2).
Scheme 1
Scheme 1
Structures of UNK A, identified as homoarsenocholine, AC2, and related As species. *hypothetical, not reported yet.
See this image and copyright information in PMC

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