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Comment
. 2018 Sep;24(9):733-735.
doi: 10.1016/j.molmed.2018.07.002. Epub 2018 Jul 17.

pSTAT3+ Reactive Astrocytes Promote Brain Metastasis

Minhong Shen  1 , Yibin Kang  2
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pSTAT3+ Reactive Astrocytes Promote Brain Metastasis

Minhong Shen et al. Trends Mol Med. 2018 Sep.

Abstract

The tumor microenvironment contains heterogeneous populations of stromal cells with important roles in cancer progression and metastasis. In a recent study published in Nature Medicine, pSTAT3+ reactive astrocytes were found to promote brain metastasis by altering the tumor microenvironment, and represent a promising target for the treatment of brain metastasis.

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  • STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.
    Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Ramón Y Cajal S, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torre C, Piñeiro-Yáñez E, Hernández-Laín A, Bertero L, Poli V, Sanchez-Martinez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M. Priego N, et al. Nat Med. 2018 Jul;24(7):1024-1035. doi: 10.1038/s41591-018-0044-4. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892069

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