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. 2018 Sep;121(3):281-284.
doi: 10.1016/j.anai.2018.05.035. Epub 2018 Jul 18.

Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference

Jonathan M Spergel  1 , Evan S Dellon  2 , Chris A Liacouras  3 , Ikuo Hirano  4 , Javier Molina-Infante  5 , Albert J Bredenoord  6 , Glenn T Furuta  7 ; participants of AGREE
Affiliations

Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference

Jonathan M Spergel et al. Ann Allergy Asthma Immunol. 2018 Sep.
No abstract available

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Figures

Figure 1
Figure 1. Esophageal Eosinophilia Response
Potential response of subjects with esophageal eosinophilia. In average, 50% of patients will have improvement with high dose PPI. In the 50% of patients that do not respond to PPI, almost all (>90%) will have resolution of esophageal eosinophilia with an elemental diet. In the 50% of the patients that respond to PPI, the exact percentage that will respond to diet or swallowed steroids is unknown. This is not a proposed treatment pathway, but represents response to therapy for examining the role of antigen and diagnostic criteria.
Figure 2
Figure 2. Updated EoE diagnostic algorithm
New diagnostic algorithm. Figure reprinted with permission from Gastroenterology.
See this image and copyright information in PMC

Comment in

  • Authors' response.
    Spergel JM, Dellon ES, Liacouras CA, Hirano I, Molina-Infante J, Bredenoord AJ, Furuta GT. Spergel JM, et al. Ann Allergy Asthma Immunol. 2018 Dec;121(6):747-748. doi: 10.1016/j.anai.2018.10.015. Epub 2018 Oct 13. Ann Allergy Asthma Immunol. 2018. PMID: 30326321 Free PMC article. No abstract available.
  • A new acronym for PPI-REE?
    Hopp R. Hopp R. Ann Allergy Asthma Immunol. 2018 Dec;121(6):747. doi: 10.1016/j.anai.2018.10.003. Ann Allergy Asthma Immunol. 2018. PMID: 30502820 No abstract available.

References

    1. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342–1363. - PubMed
    1. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: Updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128:3–20e26. - PubMed
    1. Dellon E, Liacouras C, Molina-Infante J, et al. Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE conference. Gastroenterology. 2018 In Press. - PMC - PubMed
    1. Lucendo AJ, Arias A, Molina-Infante J. Efficacy of Proton Pump Inhibitor Drugs for Inducing Clinical and Histologic Remission in Patients With Symptomatic Esophageal Eosinophilia: A Systematic Review and Meta-Analysis. Clin Gastroenterol Hepatol. 2016;14:13–22.e11. - PubMed
    1. Dellon ES, Speck O, Woodward K, et al. Clinical and Endoscopic Characteristics do Not Reliably Differentiate PPI-Responsive Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients Undergoing Upper Endoscopy: A Prospective Cohort Study. Am J Gastroenterol. 2013;108:1854–1860. - PMC - PubMed

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