Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug 6;150(8):1047-1049.
doi: 10.1085/jgp.201812151. Epub 2018 Jul 20.

Influences: Sodium channel excitement

Gail Mandel  1
Affiliations

Influences: Sodium channel excitement

Gail Mandel. J Gen Physiol. .

Abstract

Mandel reflects on the influence that a very broad training had on her scientific career.

PubMed Disclaimer

Figures

None
Shown is the cloned genomic sequence of the 5′ flanking region of the brain type II sodium channel gene that has hung on my office wall for over 20 yr. Sequences identified by red tape identify the repressor sequences that keep the promoter region (colocalized with coffee stains at bottom) off in nonneuronal cells. The repressor protein REST was shown ultimately to bind to the repressor sequences. Boxes encompass a specialized DNA sequence caused by a transposon insertion whose function is unknown but may someday make me famous.
See this image and copyright information in PMC

References

    1. Hille B. 1984. Ionic Channels of Excitable Membranes. Simauer Press, Sunderland, MA.
    1. Tanabe T., et al. . 1990. Nature. 344:451–453. 10.1038/344451a0 - DOI - PubMed
    1. Noda M., et al. . 1984. Nature. 312:121–127. 10.1038/312121a0 - DOI - PubMed
    1. Trimmer J.S., et al. . 1989. Neuron. 3:33–49. 10.1016/0896-6273(89)90113-X - DOI - PubMed
    1. Noda M., et al. . 1986. Nature. 322:826–828. 10.1038/322826a0 - DOI - PubMed

Personal name as subject

LinkOut - more resources