Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jul;559(7715):484-485.
doi: 10.1038/d41586-018-05573-4.

Histidine metabolism boosts cancer therapy

Christian Frezza
Comment

Histidine metabolism boosts cancer therapy

Christian Frezza. Nature. 2018 Jul.

Abstract

Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.

Keywords: Cancer; Medical research; Metabolism.

PubMed Disclaimer

Comment on

References

    1. Kanarek N, et al. Nature. 2018 doi: 10.1038/s41586-018-0316-7. - DOI - PubMed
    1. Farber S, Diamond LK, Mercer RD, Sylvester RF, Jr, Wolff JA. N Engl J Med. 1948;238:787–793. - PubMed
    1. Assaraf YG, Schimke RT. Proc Natl Acad Sci USA. 1987;84:7154–7158. - PMC - PubMed
    1. Roberts KG, et al. N Engl J Med. 2014;371:1005–1015. - PMC - PubMed
    1. Locasale JW. Nature Rev Cancer. 2013;13:572–583. - PMC - PubMed

LinkOut - more resources