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. 2018 Sep;35(9):1573-1583.
doi: 10.1007/s10815-018-1265-7. Epub 2018 Jul 20.

Euploid embryos selected by an automated time-lapse system have superior SET outcomes than selected solely by conventional morphology assessment

E Rocafort  1   2 , M Enciso  3 , A Leza  4 , J Sarasa  3 , J Aizpurua  5
Affiliations

Euploid embryos selected by an automated time-lapse system have superior SET outcomes than selected solely by conventional morphology assessment

E Rocafort et al. J Assist Reprod Genet. 2018 Sep.

Abstract

Purpose: We investigated if automated TLI selection may be a valuable strategy to identify those euploid embryos with the best chances of success.

Methods: This is a unicentric and retrospective study involving 244 patients undergoing preimplantational genetic screening (PGS) cycles with autologous oocytes or oocyte donation (OD) with single euploid embryo transferred. We examined euploid embryos selected for transfer based on morphology evaluation alone (PGS-only; control group) or by assessment using an automated TLI system (Eeva™; PGS-TLI group).

Results: In both, autologous oocytes and OD patients, significantly better implantation and clinical and ongoing pregnancy rates were obtained in the PGS-TLI group when euploid embryos with high implantation potential as predicted by the automated TLI System (Eeva™) were transferred compared with the PGS-only group. This improvement was also observed when only transfers of good morphological quality embryos were compared. TLI categories showed significant differences on blastocyst formation and euploidy rate.

Conclusions: Automated TLI combined with PGS is a useful prognostic tool to identify euploid embryos with the highest potential for implantation and pregnancy. Further, these results provide evidence that a healthy pregnancy does not only depend upon normal chromosomal status.

Keywords: Automated time-lapse imaging; In vitro fertilization; Oocyte donation; Pregnancy rates; Preimplantation genetic screening.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of Day 3 (a), blastocyst (b), and euploid (c) rate by TLI Eeva categories for autologous oocytes (IVF) and OD embryos
Fig. 2
Fig. 2
Implantation rates and ongoing pregnancy rates comparing all transfers to only good quality (GQ) embryo morphology transfers for autologous oocytes (IVF) (a) or OD (b) cycles
See this image and copyright information in PMC

Comment in

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