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Observational Study
. 2019 Jan;16(1):63-70.
doi: 10.1007/s10388-018-0630-z. Epub 2018 Jul 20.

Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal cancer

Tetsuya Abe  1 , Takahiro Hosoi  2 , Ryosuke Kawai  2 , Norihisa Uemura  2 , Eiji Higaki  2 , Byonggu An  2 , Jiro Kawakami  2 , Takuya Saito  2 , Yasuhiro Shimizu  2
Affiliations
Observational Study

Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal cancer

Tetsuya Abe et al. Esophagus. 2019 Jan.

Abstract

Background: We clarified the effects of perioperative enteral supplementation with glutamine, fiber, and oligosaccharide (GFO) after an esophagectomy on preventing surgical stress.

Methods: Of 326 patients with esophageal cancer, 189 received GFO administration (GFO group) and 137 did not (control group). The propensity score matching method was used to identify 89 well-balanced pairs of patients to compare postoperative laboratory parameters and clinical and postoperative outcomes.

Results: The duration of the systemic inflammatory response syndrome (SIRS) was significantly shorter in the GFO group compared to the control group (p = 0.002). Moreover, the lymphocyte/neutrophil ratio (L/N ratio) had significantly recovered in the GFO group on postoperative day-3, and the CRP value was significantly lower in the GFO group than that in the control group on postoperative day-2.

Conclusions: Perioperative use of enteral supplementation with glutamine, fiber, and oligosaccharide likely contributes to a reduction in early surgical stress after an esophagectomy. These beneficial effects can bring about early recovery from postoperative immunosuppressive conditions after radical esophagectomy.

Keywords: Esophagectomy; Nutrition; Surgical stress.

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References

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