Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar;180(3):574-579.
doi: 10.1111/bjd.17013. Epub 2018 Oct 5.

International Initiative for Outcomes (INFO) for vitiligo: workshops with patients with vitiligo on repigmentation

V Eleftheriadou  1 , I Hamzavi  2 , A G Pandya  3 , P Grimes  4 , J E Harris  5 , R H Huggins  2 , H W Lim  2 , N Elbuluk  6 , B Bhatia  2 , A Tovar-Garza  3 , A F Nahhas  2 , T Braunberger  2 , K Ezzedine  7
Affiliations

International Initiative for Outcomes (INFO) for vitiligo: workshops with patients with vitiligo on repigmentation

V Eleftheriadou et al. Br J Dermatol. 2019 Mar.

Abstract

Background: There is no cure or firm clinical recommendations for the treatment of vitiligo. One of the main issues is the heterogeneity of outcome measures used in randomized controlled trials for vitiligo.

Objectives: To define successful repigmentation from the patients' point of view and to propose how and when repigmentation should be evaluated in clinical trials in vitiligo.

Methods: We conducted three workshops with patients with vitiligo and their parents or caregivers. Workshop 1 was held at World Vitiligo Day (Detroit, MI), workshop 2 at the University of Texas Southwestern Medical Center and workshop 3 at the Vitiligo and Pigmentation Institute of Southern California, University of California.

Results: Seventy-three participants were recruited. Consensus on the following questions was achieved unanimously: (i) the definition of 'successful repigmentation' was 80-100% of repigmentation of a target lesion and (ii) both an objective and a subjective scale to measure repigmentation should be used.

Conclusions: This was the largest patients' outcomes workshop. We followed the guidance from the CSG-COUSIN and the Vitiligo Global Issues Consensus Group. Our recommendations to use percentage of repigmentation quartiles (0-25%, 26-50%, 51-79%, 80-100%) and the Vitiligo Noticeability Scale are based on the best available current evidence. A limitation of the research is that the workshops were conducted only in the U.S.A., due to pre-existing organisational support and the availability of funding.

PubMed Disclaimer