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. 2018 Sep;7(9):4308-4314.
doi: 10.1002/cam4.1679. Epub 2018 Jul 20.

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Reiko Imai  1 , Tadashi Kamada  1 , Nobuhito Araki  2 ; Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas
Collaborators, Affiliations

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Reiko Imai et al. Cancer Med. 2018 Sep.

Abstract

Carbon ion radiotherapy is known for its high-precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients' median age was 54 years, and the median follow-up period was 49.4 (range 6.4-146.4) months. The median tumor volume was 356 cm3 . The 5-year local control, overall survival, and disease-free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.

Keywords: carbon ion radiotherapy; charged particle therapy; radiotherapy; soft tissue sarcoma.

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Figures

Figure 1
Figure 1
Dose distribution of carbon ion beams in a retroperitoneal grade 3 pleomorphic spindle cell sarcoma (red line, 90% isodose of the prescribed dose 70.4 Gy (RBE)/16 fractions/4 wk with three ports). The planning target volume was 500 cm3
Figure 2
Figure 2
Local control, overall survival, and disease‐free survival rate in 128 patients
Figure 3
Figure 3
Overall survival in patients with metastases according to the first metastatic site. In patients in whom the first metastasis sites were the lungs, the OS was significantly lower than those in whom the first metastasis sites were not the lungs (P = 0.01)
See this image and copyright information in PMC

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