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Review
. 2018 Oct;5(5):755-763.
doi: 10.1002/ehf2.12316. Epub 2018 Jul 20.

Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues

Emmanuelle Berthelot  1   2 , Fabrice Bauer  3 , Jean-Christophe Eicher  4 , Erwan Flécher  5   6 , Barnabas Gellen  7 , Julien Guihaire  8 , Damien Guijarro  9 , Gérald Roul  10 , Muriel Salvat  11 , Christophe Tribouilloy  12   13 , Florian Zores  14 , Nicolas Lamblin  15 , Pascal de Groote  16   17 , Thibaud Damy  18
Affiliations
Review

Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues

Emmanuelle Berthelot et al. ESC Heart Fail. 2018 Oct.

Abstract

Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improve the therapeutic management of these patients. Nowadays, despite the recent guidelines published on the subject, several points remain unclear or debated, and until now, no study has demonstrated the efficacy of any treatment. The aim of this review is to report the evolution of the concepts on post-capillary PH (diagnosis, prevalence, prognosis, and therapeutics). The main issues are raised, focusing especially on the link between structural alterations and haemodynamic abnormalities, to discuss the possible reasons for treatment failures and future potential targets.

Keywords: Classification; Diagnosis; Heart failure; Heart transplantation; Pathophysiology; Pulmonary hypertension; Treatment.

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References

    1. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González‐Juanatey JR, Harjola V‐P, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, Authors/Task Force Members , Document Reviewers . 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016; 37: 2129–2200. - PubMed
    1. Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Crespo Leiro M, Drozdz J, Fruhwald F, Gullestad L, Logeart D, Fabbri G, Urso R, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors AA, Nielsen OW, Zannad F, Tavazzi L, Heart Failure Association of the European Society of Cardiology (HFA) . EURObservational Research Programme: regional differences and 1‐year follow‐up results of the Heart Failure Pilot Survey (ESC‐HF Pilot). Eur J Heart Fail 2013; 15: 808–817. - PubMed
    1. Logeart D, Isnard R, Resche‐Rigon M, Seronde M‐F, de Groote P, Jondeau G, Galinier M, Mulak G, Donal E, Delahaye F, Juilliere Y, Damy T, Jourdain P, Bauer F, Eicher J‐C, Neuder Y, Trochu J‐N, Heart Failure of the French Society of Cardiology . Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study. Eur J Heart Fail 2013; 15: 465–476. - PubMed
    1. de Groote P, Isnard R, Clerson P, Jondeau G, Galinier M, Assyag P, Demil N, Ducardonnet A, Thebaut J‐F, Komajda M. Improvement in the management of chronic heart failure since the publication of the updated guidelines of the European Society of Cardiology. The Impact‐Reco Programme. Eur J Heart Fail 2009; 11: 85–91. - PubMed
    1. Ghio S, Gavazzi A, Campana C, Inserra C, Klersy C, Sebastiani R, Arbustini E, Recusani F, Tavazzi L. Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. J Am Coll Cardiol 2001; 37: 183–188. - PubMed