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Comment
. 2018 Aug;94(2):242-243.
doi: 10.1016/j.kint.2018.03.023.

Crossroads of metabolism and CKD

Takehiro Suzuki  1 , Takaaki Abe  2
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Free article
Comment

Crossroads of metabolism and CKD

Takehiro Suzuki et al. Kidney Int. 2018 Aug.
Free article

Erratum in

Abstract

Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even after statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein. Their finding develops a new aspect for diagnosing and predicting the prognosis of CKD.

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