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Review
. 2018 Aug;45(3):489-502.
doi: 10.1016/j.ucl.2018.03.015. Epub 2018 Jun 15.

Imaging of Prostate Cancer Using Fluciclovine

Bital Savir-Baruch  1 , Lucia Zanoni  2 , David M Schuster  3
Affiliations
Review

Imaging of Prostate Cancer Using Fluciclovine

Bital Savir-Baruch et al. Urol Clin North Am. 2018 Aug.

Abstract

Prostate cancer is the most common cancer and the second leading cause of cancer death in men in the United States. Despite high prevalence, diagnosis and surveillance is limited due to indolent biology. Functional imaging techniques improved the ability to detect disease. Amino acids are building blocks of proteins and intracellular transport is upregulated in prostate cancer. Normal biodistribution patterns of fluciclovine include uptake in the liver and pancreas with minimal to no urine excretion, a distinct advantage for prostate cancer imaging. This review provides a detailed overview of the use of F-18 fluciclovine PET in prostate cancer imaging.

Keywords: Axumin; CT; FACBC; Fluciclovine; PET; Prostate.

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