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Comment
. 2018 Aug;138(8):1694-1696.
doi: 10.1016/j.jid.2018.04.018.

SATB1 Is a Pivotal Epigenetic Biomarker in Cutaneous T-Cell Lymphomas

Sandrine Poglio  1 , Jean-Philippe Merlio  2
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Comment

SATB1 Is a Pivotal Epigenetic Biomarker in Cutaneous T-Cell Lymphomas

Sandrine Poglio et al. J Invest Dermatol. 2018 Aug.
Free article

Abstract

The SATB1 protein has been the focus of two recent studies of cutaneous T-cell lymphomas. Fredholm et al. observed a stage-related decrease of SATB1 expression in epidermotropic cutaneous T-cell lymphomas. SATB1 was negatively regulated by STAT5 through microRNA-155, which in turn triggered enhanced expression of T helper type 2 cytokines such as IL-5 and IL-9. In parallel, Sun et al. found that SATB1 expression was up-regulated by promoter demethylation in a subset of cutaneous anaplastic lymphoma and was associated with T helper type 17 polarization in patients with better therapeutic responses.

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  • SATB1 Defines a Subtype of Cutaneous CD30+ Lymphoproliferative Disorders Associated with a T-Helper 17 Cytokine Profile.
    Sun J, Yi S, Qiu L, Fu W, Wang A, Liu F, Wang L, Wang T, Chen H, Wang L, Kadin ME, Tu P, Wang Y. Sun J, et al. J Invest Dermatol. 2018 Aug;138(8):1795-1804. doi: 10.1016/j.jid.2018.02.028. Epub 2018 Mar 3. J Invest Dermatol. 2018. PMID: 29510190
  • SATB1 in Malignant T Cells.
    Fredholm S, Willerslev-Olsen A, Met Ö, Kubat L, Gluud M, Mathiasen SL, Friese C, Blümel E, Petersen DL, Hu T, Nastasi C, Lindahl LM, Buus TB, Krejsgaard T, Wasik MA, Kopp KL, Koralov SB, Persson JL, Bonefeld CM, Geisler C, Woetmann A, Iversen L, Becker JC, Ødum N. Fredholm S, et al. J Invest Dermatol. 2018 Aug;138(8):1805-1815. doi: 10.1016/j.jid.2018.03.1526. Epub 2018 May 8. J Invest Dermatol. 2018. PMID: 29751003

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