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Comment
. 2018 Sep;41(9):570-573.
doi: 10.1016/j.tins.2018.07.001. Epub 2018 Jul 19.

Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change

Jürgen G Haas  1 , Richard Lathe  2
Affiliations
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Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change

Jürgen G Haas et al. Trends Neurosci. 2018 Sep.

Abstract

Two papers in Neuron provide compelling new indications of a link between herpesviruses and Alzheimer's disease (AD). Readhead et al. report an increased abundance of human herpesviruses 6A and 7 (HHV-6A/7) in AD brain, whereas Eimer et al. show that binding of the AD signature protein, Aβ, to herpes simplex virus type 1 (HSV-1) and HHV-6 surface glycoproteins causes fibrillar Aβ agglutination that can protect against viral challenge.

Keywords: HHV-6; HHV-7; HSV-1; Neurodegeneration; antimicrobial protein; herpesvirus.

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