Comment
doi: 10.1016/j.tins.2018.07.001.
Epub 2018 Jul 19.
Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change
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- PMID: 30033181
- DOI: 10.1016/j.tins.2018.07.001
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Comment
Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change
Trends Neurosci.
2018 Sep.
Abstract
Two papers in Neuron provide compelling new indications of a link between herpesviruses and Alzheimer's disease (AD). Readhead et al. report an increased abundance of human herpesviruses 6A and 7 (HHV-6A/7) in AD brain, whereas Eimer et al. show that binding of the AD signature protein, Aβ, to herpes simplex virus type 1 (HSV-1) and HHV-6 surface glycoproteins causes fibrillar Aβ agglutination that can protect against viral challenge.
Keywords: HHV-6; HHV-7; HSV-1; Neurodegeneration; antimicrobial protein; herpesvirus.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Comment on
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Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.Neuron. 2018 Jul 11;99(1):64-82.e7. doi: 10.1016/j.neuron.2018.05.023. Epub 2018 Jun 21. Neuron. 2018. PMID: 29937276 Free PMC article.
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Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.Neuron. 2018 Jul 11;99(1):56-63.e3. doi: 10.1016/j.neuron.2018.06.030. Neuron. 2018. PMID: 30001512 Free PMC article.
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