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Editorial
. 2018 Jun 23;5(5-6):126-127.
doi: 10.18632/oncoscience.417. eCollection 2018 May.

A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis

Dina S Stepanova  1 , Lanita Braun  1 , Jonathan Chernoff  1
Affiliations
Editorial

A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis

Dina S Stepanova et al. Oncoscience. .
No abstract available

Keywords: fatty acid synthesis; neurofibromatosis 2; small molecule inhibitors.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no potential conflicts of interest.

Figures

Figure 1
Figure 1. Differential effects of manipulating malonyl-coA levels in Nf2-null cells
(A) Small molecules that increase malonyl-CoA levels by increasing its synthesis or by reducing its catabolism; (B) Effect of chemical inhibition of PDK on cerulenin toxicity. The PDK inhibitor sodium dichloroacetate (50 mM) was added together with the indicated concentrations of cerulenin, 4 hours after cell seeding, and cells were then incubated for 48 hours. Experiments were repeated 3 times. Mean values and 95% confidence intervals are shown. MEF Nf2−/− - Nf2-knockout murine embryonic fibroblasts, MEF Nf-2f/f – wild-type murine embryonic fibroblasts, KT21 – malignant NF2-deficient human meningioma cells, Aco7 – normal human arachnoid cells.
See this image and copyright information in PMC

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