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Editorial
. 2018 Jun 23;5(5-6):130-131.
doi: 10.18632/oncoscience.419. eCollection 2018 May.

Poldip2 takes a central role in metabolic reprograming

Felipe Paredes  1 , Izabela Suster  1 , Alejandra San Martin  1
Affiliations
Editorial

Poldip2 takes a central role in metabolic reprograming

Felipe Paredes et al. Oncoscience. .
No abstract available

Keywords: TCA; cancer; hypoxia; lipoylation; poldip2.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no potential conflicts of interest.

Figures

Figure 1
Figure 1. Poldip2 downregulation under hypoxia inhibits the lipoylation and activity of Pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (α-KGDH)
As a consequence of tricarboxylic acid (TCA) cycle inhibition, α-KG is reduced while acetyl CoA is accumulated modifying downstream signaling pathways. 2OGXs: 2-oxoglutarate-dependent oxygenases; FA: fatty acids.
See this image and copyright information in PMC

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