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Review
. 2018 Jul;4(7):e000197.
doi: 10.1099/mgen.0.000197. Epub 2018 Jul 23.

Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae

Hayley Wilson  1 , M Estée Török  1   2   3
Affiliations
Review

Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae

Hayley Wilson et al. Microb Genom. 2018 Jul.

Erratum in

Abstract

Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the advances made by modern medical care over the past century. The World Health Organization has recently published a global priority list of antibiotic-resistant bacteria, which includes extended-spectrum β-lactamase-producing Enterobacteriaceae and carbapenemase-producing Enterobacteriaceae. In this review, we highlight the mechanisms of resistance and the genomic epidemiology of these organisms, and the impact of AMR.

Keywords: CPE; ESBL; Enterobacteriaceae; Gram-negative; antimicrobial resistance.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Composite figure demonstrating the prevalence and characteristics of carbapenem resistance in Europe. (a) Percentage of invasive isolates resistant to carbapenem antibiotics as determined by the European Centre for Disease Prevention and Control in the Antimicrobial Resistance Surveillance in Europe 2015 report [11]. Each country is coloured according to the percentage of submitted K. pneumoniae isolates that were non-susceptible to doripenem, imipenem or meropenem. (b) Pie charts indicating the distribution of carbapenem-resistance mechanisms in K. pneumoniae isolates submitted to the EuSCAPE study [52]. Mechanisms are coloured according to the key. ‘Other’ mechanisms: no KPC, NDM, OXA-48 or VIM genes detected. (c) Overall number of K. pneumoniae isolates submitted by each participating country in the EuSCAPE study.
See this image and copyright information in PMC

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