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Review
. 2018 Nov:94:210-218.
doi: 10.1016/j.neubiorev.2018.07.009. Epub 2018 Jul 20.

Behavioral tagging: Plausible involvement of PKMζ, Arc and role of neurotransmitter receptor systems

Shruti Vishnoi  1 , Mehar Naseem  1 , Sheikh Raisuddin  1 , Suhel Parvez  2
Affiliations
Review

Behavioral tagging: Plausible involvement of PKMζ, Arc and role of neurotransmitter receptor systems

Shruti Vishnoi et al. Neurosci Biobehav Rev. 2018 Nov.

Abstract

There are many evidences in support of Behavioral Tagging hypothesis that relies on the setting of a learning tag and the synthesis of plasticity related proteins (PRPs). It explains that how a learning tag produced as a result of weak training can be paired up with PRPs that arrive as a result of novelty and consequently lead to long lasting memories. In the following review we have focused on possible involvement of PKMζ, Arc as PRPs and neurotransmitter receptor systems ACh, metabotropic glutamate in behavioral tagging along with evidences in support of involvement of dopamine, NMDA glutamate and β-adrenergic receptor systems in behavioral tagging.

Keywords: Behavioral tagging; Learning; Memory; Plasticity related proteins; Synaptic plasticity.

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